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K-9 Advantix by Bayer - #1 veterinary recommended flea and tick spot on!A once-a-month topical tick, mosquito and flea treatment for dogs and puppies 7 weeks of age and older of any size. The two unique ingredients that work synergistically against parasites are imidacloprid and permethrin. Each affects parasite nerve cells at different sites. When combined, the neurotoxic effect against parasites is enhanced, leading to rapid paralysis and death of the parasites. Kills up to 98.3% of mosquitoes, providing protection from the West Nile Virus. Protects against Deer ticks, American dog ticks, Lone Star ticks and Brown dog ticks repelling 98.5%. Ticks die without biting and spreading disease. The active ingredient imidacloprid stops fleas from biting in less than 5 minutes and kills them before they lay eggs and also kills larvae before they develop into biting fleas, so there is no need for an IGR. It also remains effective after swimming or bathing.