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How often should these be replaced? It depends on what chemicals and / or particulates you are breathing. For many chemicals 3M and OSHA recommend replacing filters after an 8-hour work shift MINIMUM. NASUM 8200,308, M101, M201, M301, M401 Face Cover Approved Replacement Accessories. Package Includes: 4 x Filter Cotton 2 x Filter Boxes 2 x Filter Covers NASUM filter box is suitable for 8200,308, M101, M201, M301, M401 series products, you can buy them together for long-term use. Specification: Material: cotton, activated carbon, plastic Features: replaceable cotton and reusable filter box Size: Interface diameter: 82mm Thickness: 44mm When to change the cotton? 8 hours protection is a reasonable expectation of each filter. When the user feels that the breathing resistance is obviously too large, the human body feels uncomfortable, or the filter dust is dirty or damaged, the filter cotton needs to be replaced.