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Reformulated Percogesic is catching people by surprise. This older OTC pain reliever is still being used for cramps, headaches, muscle pains, etc. It used to contain acetaminophen plus phenyltoloxamine. But now phenyltoloxamine is replaced with diphenhydramine. Phenyltoloxamine is just an isomer of diphenhydramine. Acetaminophen is a pain reliever and a fever reducer. Diphenhydramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Acetaminophen and diphenhydramine is a combination medicine used to treat headache, runny nose, sneezing, watery eyes, and pain or fever caused by allergies, the common cold, or the flu.