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What Is Lion's Mane Mushroom? Lion's Mane (Hercicium erinaceus) is an edible mushroom that is native to North America, Asia, and Europe. It grows on hardwoods in a single clump of dangling long spines and has been used in folk medicine for thousands of years. Benefits of Lion's Mane Mushroom? Commonly taken as a PSK supplement, Lion's Mane has a wide range of benefits ranging from brain and mood support, to digestive and stomach support.* It works to support the nervous system and the heart and may aid in maintaining normal glucose levels in individuals.* Lion's Mane is rich in antioxidants.* Lion's Mane may also help fortify immune function and protect against age-related cognitive decline.*