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Traditional, or plain niacin usage has been limited particularly by so-called "nuisance" side effects including skin flushing associated with tingling and warmth. ENDUR-ACIN eliminates for most individuals the unpleasant skin flushing that occurs when taking niacin. ENDUR-ACIN utilizes a unique wax-matrix process that ensures uniform, continuous release of niacin over 6 – 8 hours. This greatly reduces stomach upset associated with a high concentration of niacin and skin flushing associated with a rapid rise in blood levels. ENDUR-ACIN is usually well tolerated in single doses of 500 - 750 mg. Higher single doses can increase the likelihood of flushing, and can therefore be divided into a twice daily regimen to minimize the chance of side effects. Do not use ENDUR-ACIN if you have a known hypersensitivity to niacin or active liver disease. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.