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Cytokines and Chemokines in Infectious Diseases Handbook
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About Cytokines And Chemokines In Infectious Diseases
Product Description A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections. Review "The material in this handbook is compiled in such a way that the handbook acts as an intersection of the disciplines of immunology and infectious diseases. Individuals from disciplines on either side of the fence will find this a useful resource for learning about the interplay of host humeral immunity and various infections...this book will provide a useful resource as well as a guide for those interested in learning more about cytokines and chemokines in infectious disease." -Clinical Infectious Diseases From the Back Cover Recent years have witnessed rapid growth in new information on the crucial role played by cytokines and chemokines in human disease, as well as on the exciting possibilities they offer for developing novel therapies and for optimizing vaccine performance. In the Cytokines and Chemokines in Infectious Diseases Handbook, international leaders in the field comprehensively review what is known about the responses of cytokines and chemokines to a variety of human infectious diseases, including gram-negative and gram-positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide range of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given micro-organism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections. The book also offers important information for those working in biodefense research through its illustration of the role of cytokines and chemokines in modulating host-pathogen interactions and vaccine responses. Comprehensive and cutting-edge, the Cytokines and Chemokines in Infectious Diseases Handbook summarizes all the new scientific and clinical discoveries essential to understanding the importance of cytokines and chemokines in human infectious diseases, and demonstrates how best to utilize their unique properties in the design and development of effective new therapeutic agents.
