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The new edition includes a brief account of major sub-types of ion channels in cardiac and vascular smooth muscle, as well as new sections on intracellular mechanisms of vasodilatation, the role of adhesion molecules in white cell migration in inflammation and mechanisms of action of metabolic vasodilators. A single chapter on cardiac excitation has been split into two updated chapters on the cardiac myocyte and cardiac electrical system, the sections on caardiac and coronary mechanoreceptor reflexes and on decompensated shock have been updated, and completely new accounts of integrated cardiovascular responses to feeding, ageing, systemic hypoxia and high altitude added. This introductory text has been written with the first-year student in mind and assumes no prior knowledge of the subject. As a further aid to the student preparing for examinations, the second edition contains two new features - a summary at the end of every chapter and a detailed set of Learning Objectives, presented as an Appendix. The depth of coverage also makes this edition useful, however, for the more advanced student, research student or Fellowship/Membership candidate seeking a bridge between the general physiology textbook and the more specialised monograph. Although human heart and circulation are emphasized wherever possible, students of general mammalian cardiovascular physiology will also find it a suitable reference.